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A fundamental study of oral exfoliative cytology. Changes in oral mucosa depending on area, sex, age, complete denture and pregnancy.
Title: A fundamental study of oral exfoliative cytology. Changes in oral mucosa depending on area, sex, age, complete denture and pregnancy.
Author: Ryukei MIYASHITA; Shigeki YABE; Hideo OSAWA; Takashi JOSHITA (Clinical Laboratory, Gunma University Hospital, Gunma University School of Medicine)
Source: The Journal of the Japanese Society of Clinical Cytology; ISSN:0387-1193; VOL.27; NO.4; PAGE.484-497; (1988)
Abstract: The purpose of this study was to obtain a clearer understanding, from a cytological point of view, of changes in oral mucosa according to area, sex, age, pregnancy, and especially denture use. One hundred thirty-five healthy subjects, including children, adults, and the aged, were investigated. The aged subjects were classified as denture wearers and nonwearers. The following six different areas of oral mucosa were examined from the viewpoint of exfoliative cytology and, to some extent, histology: hard palate, soft palate, cheek, maxillary anterior gingiva, mandibular anterior gingiva, and lower labium.
1. A high rate of keratinization was found in areas of hard palate and maxillary and mandibular gingiva regardless of sex or age, while the rate was lower in areas of the cheek, soft palate, and lower labium.
2. A difference in the rate of keratinization due to sex was recognized among adults and aged denture wearers and non-wearers. Similar results were not found in children. Females showed a lower tendency toward keratinization in the gingiva than males. A similar tendency was found in the hard palate of denture wearers. These findings seem to indicate that sex hormones play a role in changes in keratinization in the oral mucosa.
3. Changes in keratinization with age were identical in both males and females. The rate of keratinization in gingiva increased from childhood to adulthood, then decreased with advancing age.
4. A marked decrease in keratinization was observed in the hard palate of both male and female denture wearers. Similar results with a less marked decrease were also obtained for the gingiva.
5. A noticeable decrease in keratinization, mainly in the area of the gingiva, was recognized among pregnant as compared with non-pregnant women.
6. Exfoliative cytological findings were generally consistent with histological findings.
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